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The stages of a cancer research trial

A cancer research trial goes through a number of stages before, during and after recruiting patients.

New Proposal

Definition: A new trial concept, protocol synopsis or full protocol submitted to the TROG Scientific Committee (TSC) for consideration of presentation and subsequent voting by the TROG Membership at the TROG Annual Scientific Meeting (ASM)

Start: New Proposal application form received at TCOO

End: New Proposal approved for development

Approved for Development

Definition: This phase commences when a new proposal received the endorsement of TROG Membership at the TROG ASM and is approved for development by the TSC.

Start: New Proposal approved for development


End: Trial approved for site activation to commence

Approved for Activation

Definition: This phase commences when a trial in development has met the ten TROG trial development milestones to the satisfaction of the TSC and given permission to commence Site Activation Processes. A TROG number will be allocated at the commencement of this phase.

Start: Trial approved for site activation to commence

End: Activation of first trial site

Open to Accrual

Definition: A trial is considered as open (to accrual) when the first Trial Site has submitted all required regulatory and ethical documentation and has been approved for activation by the Trial Coordinating Centre.

Start: Activation of first trial site

End: Accrual of last patient

Closed to accrual

Definition: A trial is considered closed to accrual after the last patient has been recruited. During the closed phase, patients will complete follow up, the main analyses will occur and processes implemented to complete the trial.

Start: Accrual of last patient


End: Official notification from the TROG Scientific Committee indicating that trial is considered to be completed.

Completed

Definition: A trial is considered to be completed when the final follow up has occurred, the trial database has been locked all analyses have been performed and published, trial sites have been closed and records archived.

We are thankful to our 14,500 patients who have participated in our research. Please continue the generous support.